Laboratory for Neural Circuit Repair in CNS Trauma

Dr. Yaobo Liu, Ph.D. and M.D. Professor of Neuroscience and Doctoral Supervisor. Member of the CPPCC of Suzhou, Distinguished Professor at Soochow university. Deputy Director of institute of Neuroscience, Soochow University. Deputy Chairman of the Soochow University Committee of China Democratic League.Chief expert of National Major Research Projects. Technology leader of Jiangsu Neurological Disease Diagnosis and Treatment Technology Engineering Research Center. Principal investigator of the Laboratory for Neural Circuit Repair in CNS Trauma. Jiangsu Innovative and Entrepreneurial talent. Jiangsu Innovative and Entrepreneurial Talent Team. Jiangsu 333 Project Talent, Jiangsu Six Peaks Talent. Dr. Liu’s research focus on studying the neural regeneration and neural circuit re-establishment in CNS trauma. Some of findings have been published in Nature Neuroscience, Journal of Neuroscience, Cell Research, EMBO Journal, Cell Discovery, Advanced Functional Materials, Nature Communications, etc. He has received funding from a number of national, provincial and ministerial level scientific research projects (23 projects in total), including National Major Research Project, National Natural Science Foundation key projects, National Major Scientific Research Program (973), National Key Research and Development Plan, Jiangsu Province Key R&D Plan, etc. Furthermore, he holds 7 international and national patents. He won a second prize for provincial and ministerial science and technology progress award. He also contributed to the writing of three scientific books.

Other academic positions or memberships for Dr. Liu: Appraisal expert for the National Natural Science Foundation of China, the key research and development program project of the Ministry of Science and Technology, and the national major talent project of the Ministry of Education. Section Editor in CNS trauma of Experimental Neurology.Editorial Board member of Annals of Clinical and Translational Neurology. Member of the Society for Neuroscience (SfN) andthe National Neurotrauma Society (NNS). Committee member of the Neural Development & Regeneration Branch and Neuroglial Cells Branch of the Chinese Neuroscience Society.Standing committee member of the Neural regeneration and Repair Branch of Chinese Research Hospitals Association, and deputy director of the Basic Neural regeneration Group and Spinal Cord Injury Cell Therapy Research Group. Standing Committee member of the Science and Technology Management Evaluation Branch of Chinese Association of Rehabilitation Medicine. Committee member of the Regenerative Medicine Translational Research Branch of Genetic Society of China. Committee member of the Stem Cell Physiology Branch of Chinese Association for Physiological Sciences. Director of the Jiangsu Neuroscience Society.

Selected Peer-reviewed Publications

1、Kai Zhou^#, Wei Wei^#, Dan Yang^#, Hui Zhang, Wei Yang, Yunpeng Zhang, Yingnan Nie, Mingming Hao, Pengcheng Wang, Hang Ruan, Ting Zhang, Shouyan Wang, Yaobo Liu*. Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury. Nature Communications. 2024. 15:619. 

2、  Jun Yan^#, Yunjing Wan^#, Zhe Ji^#, Chenxi Li^#, Chengcheng Tao, Yunjiao Tang, Yuze Zhang, Yaobo Liu*, Jian Liu*. Motor Neuron-Specific Membrane Depolarization of Transected Peripheral Nerves by Upconversion Nanoparticle-Mediated Optogenetics. Advanced Functional Materials. 2023. 33(50): 2303992. 

3、Jian Wang, Peng Jiang, Wenbin Deng, Yuhui Sun, Yaobo Liu^*. Grafted human ESC-derived astroglia repair spinal cord injury via activation of host anti-inflammatory microglia in the lesion area. Theranostics. 2022. 12(9):4288-4309.

4、Wei Wei^#, Mingming Hao^#, Kai Zhou, Yongfeng Wang, Qifeng Lu, Hui Zhang, Yue Wu, Ting Zhang*, Yaobo Liu*. In situ multimodal transparent electrophysiological hydrogel for in vivo miniature two-photon neuroimaging and electrocorticogram analysis. Acta Biomaterialia. 2022. 152:86-99.

5、Xin Duan^#, Yarong Gao^#, Yaobo Liu*. Ryk regulates Wnt5a repulsion of mouse corticospinal tract through modulating planar cell polarity signaling. Cell Discovery. 2017.3:17015.

6、Zhenhui Huang^#, Yarong Gao^#, Yuhui Sun^#, Yue Yin, Chao Zhang, Yasushi Shimoda, Kazutada Watanabe, Yaobo Liu*. NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells. EMBO Journal. 2016, 35(16):1745-1765. 

7、Lijuan Song^#, Yuehui Liu^#, Yang Yu^#, Xin Duan, Shening Qi, Yaobo Liu*. Shh signaling guides spatial pathfinding of raphespinal tract axons by multidirectional repulsion. Cell Research. 2012, 22(4):697-716.

8、Yaobo Liu, Xiaofei Wang, Chin-Chun Lu，Rachel Kerman, Oswald Steward, Xiao-Ming Xu, Yimin Zou*. Repulsive Wnt signaling inhibits axon regeneration after CNS injury. Journal of Neuroscience. 2008, 28 (33): 8376-8382.

9、Yaobo Liu, Jun Shi, Chin-Chun Lu, Zheng-Bei Wang, Anna I. Lyuksyutova, Xuejun Song and Yimin Zou*. Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nature Neuroscience. 2005, 8 (9):1151-1159.