Name： Hu Lifang
TeachingTitleProfessor, PI, Master tutor
Phone： 0512-65884621
E-mail： [email protected]
Speciality： 1. Neuroimmunology and pathogenesis of neurodegenerative diseases (Parkinson's disease) and exploration of drug targets2.The role of transsulfuration pathway (TSP) in the processes of Parkinson’s disease development
Dr. Li-Fang Hu obtained the PhD degree in the department of Pharmacology in National University of Singapore in 2010. After that, she joined in the Institute of Neuroscience in Soochow University, and was promoted as a PI of Parkinson’s disease (PD) research group in 2015. Her group is interested in understanding the molecular pathogenesis of PD, focusing on the role of microglia-mediated inflammation in the development of PD. Since 2010, she and her team has already published more than 30 articles in peer-reviewed journals including Autophagy, Aging cell Brain Behavior Immunity, and etc. Now she is a member of the Chinese and American Society for Neuroscience and member of the Chinese Pharmacology society, and serves as the peer reviewer in several SCI journals. As a young PI, she got several grants including the National Natural Science Foundation of China and Jiangsu Province, and the National Key R&D Program of China. She was also elected as ‘high-level creative and innovative talent in Suzhou City’ (2011) and The 16th batch of six talent peaks in Jiangsu Province (2019).
Selected Publications：(* Corresponding author)
1. Tu HY, Yuan BS, Hou XO, Zhang XJ, Pei CS, Ma YT, Yang YP, Fan Y, Qin ZH, Liu CF and Hu LF*. alpha-synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson's disease.Aging Cell. 2021:e13522. (二区)
2. Yuan YQ, Wang YL, Yuan BS, Yuan X, Hou XO, Bian JS, Liu CF, Hu LF*. Impaired BS-H2S signaling axis contributes to MPTP-induced neurodegeneration in a mouse model of Parkinson's disease. Brain Behav Immun. 2018 January.67: 77-90. (二区)
3. Sheng YL, Chen X, Hou XO, Yuan X, Yuan BS, Yuan YQ, Zhang QL, Cao X, Liu CF, Luo WF*, Hu LF*. Urate promotes SNCA/alpha-synuclein clearance via regulating mTOR-dependent macroautophagy. Exp Neurol. 2017 Nov; 297: 138-147. (二区)
4. Hou XO, Yuan YQ, Sheng YL, Yuan BS, Wang YL, Zheng JY, Liu CF, Zhang XH*, Hu LF*. GYY4137, an H2S slow-releasing donor, prevents nitrative stress and a-synuclein nitration in an MPTP-mouse model of Parkinson's disease.Front Pharmacol. 2017 Oct; 8: 741. (二区)
5. Wang JD, Cao YL, Li Q, Yang YP, Jin MM, Chen D, Wang F, Wang GH, Qin ZH, Hu LF*, Liu CF*. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy. 2015;11(11):2057-2073. (一区)